RIPK1 ELISA Kit for Human(Homo sapiens) | EIAab.comRIPK1 ELISA Kit for Human(Homo sapiens)

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RIPK1 (Gene name),

Receptor-interacting serine/threonine-protein kinase 1 (Protein name ), RIPK1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RIPK1(RIP;RIP1);

Protein name:

Receptor-interacting serine/threonine-protein kinase 1;

Alternative:

Receptor-interacting protein 1(RIP-1);Cell death protein RIP;Serine/threonine-protein kinase RIP;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1.

Function:

Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

Subcellular Location:

Cytoplasm Cell membrane

Protein Attributes:

Sequence length:

671

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

671:

QALHQCSRID | LLSSLIYVSQ | N

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q13546

STRING:

9606.ENSP00000259808

UniGene:

Hs.519842

KEGG:

hsa:8737

Pfam:

PF00531

SMR:

Q13546

MIM:

603453

Uniprot:

Q13546

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ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 1

Cat.:

E15191h

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96T

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ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 1

Cat.:

E15191m

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Packing:

96T

CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 1

Cat.:

U15191h

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Packing:

96T

CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 1

Cat.:

U15191m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 1

Cat.:

P15191Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 1

Cat.:

P15191Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 1

Protein for Human Receptor-interacting serine/threonine-protein kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex."
Hsu H. , Huang J. , Shu H.-B. , Baichwal V.R. , Goeddel D.V.
Immunity4:387-396(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);AUTOPHOSPHORYLATION;MUTAGENESIS OF LYS-45;INTERACTION WITH TRADD; TRAF1; TRAF2 AND TRAF3;VARIANT VAL-438
tissue: Umbilical vein endothelial cell.
2.

Huang J. , Hsu H. , Baichwal V.R. , Goeddel D.V.
Submitted (1998-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 120
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-671 (ISOFORM 2)
tissue: Adrenal gland.
tissue: Uterus.
4.

SeattleSNPs variation discovery resource
Submitted (2004-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LYS-234
5.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-438
7.

"Homo sapiens protein coding cDNA."
Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 153-671
tissue: Brain.
8.

"RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death."
Stanger B.Z. , Leder P. , Lee T.-H. , Kim E. , Seed B.
Cell81:513-523(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-671;VARIANT VAL-438
tissue: Leukemic T-cell.
9.

"Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis."
Lin Y. , Devin A. , Rodriguez Y. , Liu Z.-G.
Genes Dev.13:2514-2526(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY CASPASE-8;MUTAGENESIS OF ASP-324
10.

"The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation."
Sanz L. , Sanchez P. , Lallena M.-J. , Diaz-Meco M.T. , Moscat J.
EMBO J.18:3044-3053(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1 AND TRAF2;DOMAIN
11.

"RIP3, a novel apoptosis-inducing kinase."
Sun X. , Lee J. , Navas T. , Baldwin D.T. , Stewart T.A. , Dixit V.M.
J. Biol. Chem.274:16871-16875(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIPK3
12.

"The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation."
Izumi K.M. , Cahir McFarland E. , Ting A.T. , Riley E.A. , Seed B. , Kieff E.D.
Mol. Cell. Biol.19:5759-5767(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BNLF1
13.

"Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis."
Li Y. , Kang J. , Friedman J. , Tarassishin L. , Ye J. , Kovalenko A. , Wallach D. , Horwitz M.S.
Proc. Natl. Acad. Sci. U.S.A.96:1042-1047(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKBKG
14.

"Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule."
Holler N. , Zaru R. , Micheau O. , Thome M. , Attinger A. , Valitutti S. , Bodmer J.L. , Schneider P. , Seed B. , Tschopp J.
Nat. Immunol.1:489-495(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome."
Habib A.A. , Chatterjee S. , Park S.-K. , Ratan R.R. , Lefebvre S. , Vartanian T.
J. Biol. Chem.276:8865-8874(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGFR
16.

"A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation."
Chen D. , Li X. , Zhai Z. , Shu H.-B.
J. Biol. Chem.277:15985-15991(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF216
17.

"Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3."
Sun X. , Yin J. , Starovasnik M.A. , Fairbrother W.J. , Dixit V.M.
J. Biol. Chem.277:9505-9511(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RIP HOMOTYPIC INTERACTION MOTIF;INTERACTION WITH RIPK3
18.

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-384;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation."
Huang J. , Teng L. , Li L. , Liu T. , Li L. , Chen D. , Xu L.-G. , Zhai Z. , Shu H.-B.
J. Biol. Chem.279:16847-16853(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZFAND5
20.

"De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling."
Wertz I.E. , O'Rourke K.M. , Zhou H. , Eby M. , Aravind L. , Seshagiri S. , Wu P. , Wiesmann C. , Baker R. , Boone D.L. , Ma A. , Koonin E.V. , Dixit V.M.
Nature430:694-699(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY TRAF2;DEUBIQUITINATION BY TNFAIP3
21.

"IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction."
Kawai T. , Takahashi K. , Sato S. , Coban C. , Kumar H. , Kato H. , Ishii K.J. , Takeuchi O. , Akira S.
Nat. Immunol.6:981-988(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAVS
22.

"Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO."
Ea C.K. , Deng L. , Xia Z.P. , Pineda G. , Chen Z.J.
Mol. Cell22:245-257(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-377;MUTAGENESIS OF LYS-377
23.

"RIP1, a kinase on the crossroads of a cell's decision to live or die."
Festjens N. , Vanden Berghe T. , Cornelis S. , Vandenabeele P.
Cell Death Differ.14:400-410(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
24.

"RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation."
Zhang H. , Zhang H. , Lin Y. , Li J. , Pober J.S. , Min W.
J. Biol. Chem.282:14788-14796(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF DAB2IP;INTERACTION WITH DAB2IP
25.

"RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."
Tian Y. , Zhang Y. , Zhong B. , Wang Y.Y. , Diao F.C. , Wang R.P. , Zhang M. , Chen D.Y. , Zhai Z.H. , Shu H.B.
J. Biol. Chem.282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBCK1
26.

"CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation."
Liao W. , Xiao Q. , Tchikov V. , Fujita K. , Yang W. , Wincovitch S. , Garfield S. , Conze D. , El-Deiry W.S. , Schuetze S. , Srinivasula S.M.
Curr. Biol.18:641-649(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RFFL;UBIQUITINATION BY RFFL
27.

"Identification of RIP1 kinase as a specific cellular target of necrostatins."
Degterev A. , Hitomi J. , Germscheid M. , Ch'en I.L. , Korkina O. , Teng X. , Abbott D. , Cuny G.D. , Yuan C. , Wagner G. , Hedrick S.M. , Gerber S.A. , Lugovskoy A. , Yuan J.
Nat. Chem. Biol.4:313-321(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-161;INHIBITION BY NECROSTATIN-1;PHOSPHORYLATION AT SER-6; SER-20; SER-25; SER-161; SER-166; SER-303; SER-320 AND SER-333
28.

"Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1."
Upton J.W. , Kaiser W.J. , Mocarski E.S.
J. Biol. Chem.283:16966-16970(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MURID HERPESVIRUS 1 VIRAL INHIBITOR OF RIP ACTIVATION
29.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
30.

"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation."
Cho Y.S. , Challa S. , Moquin D. , Genga R. , Ray T.D. , Guildford M. , Chan F.K.
Cell137:1112-1123(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION
31.

"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha."
He S. , Wang L. , Miao L. , Wang T. , Du F. , Zhao L. , Wang X.
Cell137:1100-1111(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RIPK3
32.

"Response: CARP1 regulates induction of NF-kappaB by TNFalpha."
Liao W. , Fujita K. , Xiao Q. , Tchikov V. , Yang W. , Gunsor M. , Garfield S. , Goldsmith P. , El-Deiry W.S. , Schuetze S. , Srinivasula S.M.
Curr. Biol.19:R17-R19(2009)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF34;UBIQUITINATION BY RNF34
33.

"The role of the kinases RIP1 and RIP3 in TNF-induced necrosis."
Vandenabeele P. , Declercq W. , Van Herreweghe F. , Vanden Berghe T.
Sci. Signal.3:RE4-RE4(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
34.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
35.

"Linear ubiquitination prevents inflammation and regulates immune signalling."
Gerlach B. , Cordier S.M. , Schmukle A.C. , Emmerich C.H. , Rieser E. , Haas T.L. , Webb A.I. , Rickard J.A. , Anderton H. , Wong W.W. , Nachbur U. , Gangoda L. , Warnken U. , Purcell A.W. , Silke J. , Walczak H.
Nature471:591-596(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY THE LUBAC COMPLEX
36.

"cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."
Bertrand M.J. , Lippens S. , Staes A. , Gilbert B. , Roelandt R. , De Medts J. , Gevaert K. , Declercq W. , Vandenabeele P.
PLoS ONE6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY BIRC2/C-IAP1 AND BIRC3/C-IAP2;INTERACTION WITH BIRC2/C-IAP1; BIRC3/C-IAP2 AND XIAP/BIRC4
37.

"The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways."
Wang Z. , Jiang H. , Chen S. , Du F. , Wang X.
Cell148:228-243(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN COMPLEX WITH PGAM5; RIPK3 AND MLKL
38.

"Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."
Zhao Y. , Alonso C. , Ballester I. , Song J.H. , Chang S.Y. , Guleng B. , Arihiro S. , Murray P.J. , Xavier R. , Kobayashi K.S. , Reinecker H.C.
Inflamm. Bowel Dis.18:603-612(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF2
39.

"Structural basis of RIP1 inhibition by necrostatins."
Xie T. , Peng W. , Liu Y. , Yan C. , Maki J. , Degterev A. , Yuan J. , Shi Y.
Structure21:493-499(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-294 IN COMPLEXES WITH NECROSTATIN-TYPE INHIBITORS;CATALYTIC ACTIVITY;ENZYME REGULATION;AUTOPHOSPHORYLATION
40.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-64; ILE-81; VAL-220; SER-404; VAL-443 AND VAL-569

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